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KMID : 1123920030170041031
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1031 ~ p.1036
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Effects of Tongryeong-san and Constituents Extract in Cultured Rat Myocardial Cells
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Seong Eun-Kyung
Kwon Kang-Beom
Kim In-Su
Kang Gil-Seong
Kim In-Gyu
Kim In-Seob
Ryu Do-Gon
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Abstract
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To certify the protective effect of herbal medicine against oxygen free radical-induced myocardiotoxicity, cytotoxicity was measured using TBARS assay and Beating rate in the presence of Tongryeong-san(TRS) extracts or single constituents of this prescription. Myocardial toxicity was evaluated in neonatal rat myocardiocytes in cultures. In the present study, xanthine oxidase/hypoxanthine (XO/HX) resulted in a increase in lipid peroxidation and decreases in beating rate in cultured myocardial cells. In the effect of TRS extract, it showed the prevention from the XO/HX-induced cardiotoxicity by the increases of beating rate as well as the decrease of lipid peroxidation, In the protective effect of Faeces Trogopterori(FT), Pollen Typhae(PT), Caulis Akebiae(CA) and Radix Paeoniae Rubra(PRR), all the extracts were significantly effective in the protection of XO/HX-induced cardiotoxocity in cultured myocardial cells by the increase of beating rate as well as th decrease of lipid peroxidation. From these results, they show that XO/HX is cardiotoxic in cultured myocardial cells derived from neonatal rat, and it suggests that TRS, FT, PT, CA and PRR extracts are positively effective in the blocking in XO/HX-induced cardiotoxicity.
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KEYWORD
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Tongryeong-san(通靈散), Faeces Trogopterori, Pollen Typhae, Caulis Akebiae, Paeoniae Rubra, xanthine oxidase/hypoxanthine, Myocardial cell, CardiotoKicity
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